Multiple pathways exist that make inflammation in the joints worse. These are 3 to look out for:

Biochemical Pathways of Inflammation (There are more than just three)

   ​1) Histamine Pathway

        ​a. Histamine is produced in the gut mostly ('bad' microbes)

        b. HistaDINE is the precursor molecule

        c. Dietary sugar stimulates 'bad' microbes (Yeast, Candida, Bacteria)

   ​2)   Arachidonic Acid Pathway

        ​a. From animal-derived cholesterol

   ​3)   TNF-a, IL-6 (Tumor Necrosis Factor Alpha and Interleukin-6)

        ​a. Produces a dysfunctional immune response

        b. Vitamin D deficiency causes elevations in TNF-a/IL-6

        c. Phytonutrients help block TNF-a/IL-6

References:

https://pubmed.ncbi.nlm.nih.gov/28446...

https://pubmed.ncbi.nlm.nih.gov/33568...

https://pubmed.ncbi.nlm.nih.gov/25651...

There are a whole host of conditions associated with dysfunctional immune inflammation, the list includes: Eczema, Allergies, UTIs, Irritable Bowel (IBS), IBD, Crohn's/Colitis, SIBO, Candida, GERD, Viral illnesses, Autism, Multiple Sclerosis, Lupus, Rheumatoid Arthritis, Mixed Connective Tissue Disorder, Sjrogrens, Autoimmune Thyroiditis, Migraine Headache, Neuropathy, and Fibromyalgia

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