Learn about 3 inflammation pathways in lupus and how to manage them. Discover holistic care at MGI Clinics.
“Fuel the Mind, Heal the Gut, Reclaim Immunity”
Have Lupus? Want to stop INFLAMMATION for good?
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There are many forms of inflammation that can make lupus symptoms worse. Here are 3 to look out for:
Biochemical Pathways of Inflammation (There are more than just three)
1) Histamine Pathway
a. Histamine is produced in the gut mostly ('bad' microbes)
b. HistaDINE is the precursor molecule
c. Dietary sugar stimulates 'bad' microbes (Yeast, Candida, Bacteria)
2) Arachidonic Acid Pathway
a. From animal-derived cholesterol
2) TNF-a, IL-6 (Tumor Necrosis Factor Alpha and Interleukin-6)
a. Produces a dysfunctional immune response
b. Vitamin D deficiency causes elevations in TNF-a/IL-6
c. Phytonutrients help block TNF-a/IL-6
References:
https://pubmed.ncbi.nlm.nih.gov/3374407/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218729/
https://pubmed.ncbi.nlm.nih.gov/7511020/
There are a whole host of conditions associated with dysfunctional immune inflammation, the list includes: Eczema, Allergies, UTIs, Irritable Bowel (IBS), IBD, Crohn's/Colitis, SIBO, Candida, GERD, Viral illnesses, Autism, Multiple Sclerosis, Lupus, Rheumatoid Arthritis, Mixed Connective Tissue Disorder, Sjrogrens, Autoimmune Thyroiditis, Migraine Headache, Neuropathy, and Fibromyalgia
Note:
Although I am a licensed, and practicing surgeon, with over a decade of experience helping people overcome inflammatory disease, the presented material is intended for educational purposes only and should not be construed as medical advice. Please use your best judgment and consult with a healthcare professional regarding your needs.
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"As always: Be TRUE to yourself. Surround yourself with people who affirm your wellbeing. Find a doctor who will slow down to listen. Find one who carefully considers your concerns and most of all--find one who cares."
Dr. Chanu R. Dasari MD
You hear the word inflammation thrown around a lot. Well, what
is it exactly and how does it actually happen?
Hi everyone. I'm Dr. Chanudasri. I help my
clients solve their immune inflammation and digestive dysfunction using
the Mind get immunity method.
This clinical approach has helped thousands of my patients resolve
their symptoms summon as little as six weeks without the
need for complex or costly interventions in this
video. I'll show you the three major Pathways of inflammation that
make lupus symptoms worse. I'll show
you how the inflammation works on a biochemical level and
how to avoid these damaging Pathways to reverse
inflammation fast. This topic gets a little
bit into the weeds. But I promise if you stick around till
the end, I'll review some practical points that you can use
to help avoid inflammation and resolve symptoms this
material you're about to watch is taking straight out of my mind getting immunity
or people just like you learn how to
beat their lupus symptoms for good. Even when the
diagnosis is unclear in the course. We review several
additional Pathways that can be useful for addressing inflammation
in some of my other videos. I mentioned that there are
five main triggers for Lupus inflammation and these five
triggers include diet digestion sleep stress
and exercise and if you want to
check
That video for some background take a look at the link up here. Now
before we go any further. Don't forget to like And subscribe
and hit the notification Bell to keep up to date. I make
must see videos for anyone with lupus looking
to reverse their symptoms for good.
And it's really helpful information that you probably won't get anywhere
else now on the topic of inflammation the mistake
I see most people make is that they think inflammation is
just one process, but in actuality, there's
hundreds of biochemical Pathways involved and if
your symptoms are really bad, you can have several of these Pathways
involve simultaneously knowing what
activates inflammation and how it works can help
you overcome and prevent it from happening in the first place.
That's why it's really important to be at least aware of
some of the key types of inflammation.
Now recall what I said in my other video that most inflammations
starts in your gut now you shouldn't
be surprised by this considering around 70 to 80
percent of your immune system is contained in your gut.
So when you have an inflammatory disease such as
lupus you need to take a look at what's going
on with diet and digestion frequently inflammation
starts in the intestine. So to heal inflammation, you
also need to heal the gut. So before we discuss the
three types of inflammation, if you are serious about
healing the gut to improve lupus and Achieve
results fast, check out a free training that I put
together where I walk you through the specific strategies that have helped my
clients achieve success within six weeks. You can
access it at the link down below and I know
it'll help you very much the link takes you to a page where you can enter
in your email to receive a free training on how to reverse lupus
everything you need to know is in there including free guide
with specific dietary recommendations and tons
of helpful case studies that people just like you who reverse
their
Additions for good and are now healthy the cases are
valuable because you'll see how real people deal with inflammation and how
they were able to improve their condition just by making a few small changes.
The training comes with a complete actionable game
plan for how you can do this yourself at home. So just
enter in your email at the top of the page and get started.
Now let's talk about the three types of inflammation. I recorded
this video earlier and it discusses how they immune system
is activated in three ways. The histamine pathway
is probably one of the most important ones to know here's an
example of one of my patients who had high amounts
of eosinophils due to candida overgrowth in his gut
His histamine levels were so high that all he had to do
was gently stroke his skin and in 30 seconds,
it would turn bright beat red.
This is called dermatographia and it's actually a form of
hives.
Unfortunately many people have this type of histamine
reaction always and have no clue.
I just want to correct one misconception. Most people
think that if they have allergies that it's coming from something in
the environment like grass or hay or
flowers or dust or mold.
While this is partially true, it's important
to know that most of the histamine in the human body
is actually produced in the gut by intestinal
bacteria that convert histidine into
histamine.
Histidine is an amino acid found in certain
types of protein. It gets converted into histamine, which
triggers allergic reactions in the
body.
So it's an important to limit both histidine containing foods
and histamine stimulating Foods. They include
things like shellfish peanuts and
pineapples, but the biggest stimulator is actually simple
carbohydrates, like sugars breads crackers
chips juices pasta candies and
certain types of fruit.
It turns out all of these sugary Foods Feed bad
bacteria and stimulate overgrowth of candida.
Which is a type of yeast and fungus this bad bacteria and
candida produce super high amounts of
histamine in the bloodstream, which leads the things like
allergies tiredness indigestion rashes hives
body aches and runny nose. So how
do we use this knowledge to our advantage? Well one simple
answer is a eat fewer starchy Foods.
B eat more green leafy vegetables and
high fibers Foods
C improve your intestinal Flora with regular
bowel movements two to four times a day.
probiotics also two to four times a day and phytonutrients
D stay away from foods that are high in
histidine, which is a precursor molecule to
histamine now would be a good time to point out that most
people think that you need to take an antibiotic or an
antifungal to clear intestinal bacteria overgrowth in
Candida.
The reality is all you really need to do is
have two to four bowel movements a day so that you
get rid of The Unwanted bugs in your
GI system. Then you can repopulate the system two
to four times a day with probiotics you do
this in antibiotics and antifungals are rarely needed.
Also if you happen to take an antibiotic
or antifungal just remember that it only works for the
first few days, then the GI track it's repopulated with bacteria
in Canada. Especially if the diet is bad to
summarize a histidine pathway. There are histidine amino
acids in the diet that get converted into histamine when
we eat certain foods that cause overgrowth of
bacteria and candida in the system.
This histamine that's released into bloodstream produces. Allergies
sinus drainage sore throat
itchy. Scaly dry skin, asthma shortness
of breath pain and fatigue. Okay,
we'll be moving on now.
Here is the arachidonic acid pathway.
All animal cells have a membrane wall that contains
fats and cholesterol which convert into
arachidonic acid and cytokines in
our bodies and generate inflammation. Do all
animal derived products contain arachidonic acid. No,
just me and fat containing
dairy products.
Remember the arachidonic acid doesn't come from
the protein component. It comes from the fat and the cholesterol in
the cell wall.
So for example egg whites are pure protein,
so they don't contain arachidonic acid.
Marine and Bovine collagen also do
not contain arachidonic acid.
Fat-free yogurt and bone broth are other examples.
But something like red meat has a lot of fat and cholesterol in
it. So rackodonic acid production is especially bad,
but unfortunately even white meat poultry and
fish contain substantial amounts because they
contain lipid cholesterol for this reason limiting
meat and dairy intake improves inflammation.
Now I want to talk about the salt pathway.
So here's the thing everyone knows that when they
eat large amounts of salt, they feel very bloated inflamed
the next day.
It's especially bad if you have an inflammatory disease because
the salt also increases the amount of pain in the
body.
This is no accident.
Table salt sodium chloride activates a
special type of white blood cell called th17.
These immune cells activate a pathway called
sgk1, which results in
autoimmune disease and inflammation. That's why if you
have any type of immune or inflammatory or digestive problem.
It's important to avoid salt altogether.
Now also remember that salt is contained
in lots of foods that we don't even think about.
Most packaged Foods desserts baked
goods sauces have large
amounts of sodium.
Also, I found this really surprising chicken has
a lot of sodium because they actually injected
inside the meat sometimes the saline weight
is up to 30% of the actual meat. So pay
attention you could be inadvertently making your
situation worse by eating something that you don't
even think has any salt in it, but it does
If you're wondering what a good limit is historically many
people have said two grams, which is 2,000 milligrams.
But I think even this is too high. I think
you're better off under a gram or even 0.5 grams
or 500 milligrams, which is half a gram.
And the reason I say this is that the body has ways
of extracting salt from the normal food that we
eat. Keep in mind until a couple hundred years ago when salt
was discovered as a way of preserving meat and the
salt trade became a thing humans never added salt
to anything that they ate.
it also turns out that many of the inflammatory and immune
diseases were also more common in countries
in places where they consume large amounts of salt tnf
Alpha and il-6
In my opinion, it's one of the most important.
Whenever there's a trigger for inflammation in the body, the body
has a choice either deal with it appropriately or in
a dysfunctional way.
If the immune system decides it wants to react in
an unhelpful way. Then the body will produce inflammation that
will attack its own tissue.
Il-6 and tnf Alpha are cell signaling
molecules. You can measure in the blood that predict whether
the body will have a dysfunctional response versus a
healthy response. In fact, these cytokines are
involved in a large number of chronic diseases. One
of the most potent activators of il-6 and
tnf. Alpha is fat in the
diet specifically animal fat, especially in
red meat.
But also meets in general butter Dairy and
cheese is problematic.
The folks that have the lowest il-6 and
tnf Alpha levels follow a phytonutrient diet
which have lots of healthy vegetables and healthy
fats like olive oil.
Other things that work are intermittent fasting.
Here's another interesting study which shows that even if you don't eat perfectly
increasing the amount of phytonutrients and
specifically polyphenols in the diet will
down regulate il-6 production from food
in the intestines.
Which means even if you eat pepperoni pizza, if you drink some
phytonutrient tea afterwards, for example, it blunts
the effects of the fat sort of
like a rescue mechanism.
Also, I'm going to give you another pearl of
knowledge here. One of the simplest things you can do to drive. These
levels down are to take a vitamin D
supplement turns out if you're low on vitamin D
the aisle 6 and tnf Alpha levels shoot way up.
That's one of the theories on why equatorial countries
such as Africa where they get enough vitamin D from
the sunlight have better immune responses to illness. All
right. I hope you enjoyed that video. Now. I want to know
what types of inflammation do you experience? And what have you
tried that works leave a comment below and let me know your
thoughts. Also, if you like this video help support my channel and share this
with your fellow loved ones and be sure to subscribe for more useful tips.
You can also follow me on social at dosari MD
as always, this is Dr. Chanudasari with the mindgun immunity
clinic and I'll see you next time.
1) Histamine Pathway
a. Histamine is produced in the gut mostly ('bad' microbes)
b. HistaDINE is the precursor molecule
c. Dietary sugar stimulates 'bad' microbes (Yeast, Candida, Bacteria)
2) Arachidonic Acid Pathway
a. From animal-derived cholesterol
2) TNF-a, IL-6 (Tumor Necrosis Factor Alpha and Interleukin-6)
a. Produces a dysfunctional immune response
b. Vitamin D deficiency causes elevations in TNF-a/IL-6
c. Phytonutrients help block TNF-a/IL-6