At MGI Clinics, we understand the complexity of ulcerative colitis and the significant impact it can have on daily life. For those seeking relief through natural methods, the role of inflammation cannot be overstated. Managing this condition starts with a deep understanding of the biochemical pathways driving inflammation and how a holistic approach can help.

This blog delves into the science behind inflammation and offers practical steps to manage it naturally.

‍The Connection Between Inflammation and Ulcerative Colitis

Inflammation is not a singular process but a network of biochemical pathways that, when triggered, exacerbate symptoms of ulcerative colitis. The majority of inflammation starts in the gut, where around 70-80% of the immune system resides. Understanding and addressing gut health is the cornerstone of reversing inflammation.

Let’s explore three major pathways that drive inflammation in ulcerative colitis and how to manage them effectively.

‍1. The Histamine Pathway

Histamine, a compound involved in immune responses, can play a disruptive role in ulcerative colitis when overproduced. While environmental allergens like pollen and dust can trigger histamine, most histamine in the body is produced in the gut by certain microbes.

What Triggers the Histamine Pathway?

• Dietary Sugars: Simple carbohydrates like bread, pasta, candies, and fruit juices feed harmful bacteria and fungi (like Candida) in the gut.
• Histidine-Containing Foods: Foods such as shellfish, peanuts, and pineapples contain histidine, a precursor to histamine.

Symptoms of High Histamine Levels:

• Fatigue and brain fog.
• Digestive discomfort, including bloating and diarrhea.
• Skin rashes, hives, or itchiness.
• Respiratory symptoms like runny nose or sinus drainage.

How to Manage the Histamine Pathway:

• Reduce Simple Carbohydrates: Cut back on sugary and starchy foods.
• Increase Fiber: Leafy greens, whole grains, and high-fiber foods help regulate gut bacteria.
• Optimize Gut Flora: Use probiotics and aim for 2-4 bowel movements daily to maintain a healthy gut microbiome.

‍2. The Arachidonic Acid Pathway

This pathway involves arachidonic acid, a compound derived from the fat and cholesterol in animal products. Arachidonic acid contributes to the production of cytokines, inflammatory molecules that worsen symptoms.

Foods High in Arachidonic Acid:

• Red meat and fatty cuts of poultry.
• Full-fat dairy products like butter, cheese, and cream.
• Processed meats.

Foods Low in Arachidonic Acid:

• Egg whites (free from fat and cholesterol).
• Bone broth.
• Fat-free yogurt and marine collagen.

How to Manage the Arachidonic Acid Pathway:

• Limit Animal Fats: Focus on lean protein sources and plant-based alternatives.
• Adopt a Phytonutrient-Rich Diet: Incorporate vegetables and healthy fats like olive oil, which reduce inflammatory responses.

‍3. The TNF-Alpha and IL-6 Pathway

TNF-alpha (Tumor Necrosis Factor Alpha) and IL-6 (Interleukin-6) are inflammatory molecules that the body releases during an immune response. While these molecules can be helpful in short bursts, prolonged production leads to chronic inflammation, a hallmark of ulcerative colitis.

Factors Elevating TNF-Alpha and IL-6:

• Vitamin D Deficiency: Low vitamin D levels are directly linked to increased TNF-alpha and IL-6 production.
• Poor Diet: Diets high in processed foods and low in phytonutrients fail to counteract these inflammatory markers.

How to Manage TNF-Alpha and IL-6 Levels:

• Supplement Vitamin D: Regular supplementation can lower these inflammatory markers.
• Increase Polyphenols: Found in phytonutrient-rich foods like berries, green tea, and dark leafy greens, polyphenols help downregulate inflammation.
• Incorporate Intermittent Fasting: Short fasting periods have been shown to reduce inflammation and support gut health.

‍Practical Steps for Holistic Management

A holistic approach is essential for addressing inflammation and improving symptoms of ulcerative colitis. Here are actionable steps:

1. Optimize Your Diet

• Focus on whole, unprocessed foods.
• Incorporate more vegetables, healthy fats, and lean proteins.
• Avoid sugar, refined carbohydrates, and processed snacks.

2. Stay Active

• Engage in light to moderate exercise to reduce inflammation.

3. Prioritize Restorative Sleep

• Poor sleep increases inflammatory markers, so aim for 7-9 hours of quality sleep nightly.

4. Manage Stress

• Chronic stress disrupts gut health and worsens inflammation. Practice mindfulness, yoga, or journaling to manage stress levels.

5. Seek Support from a Holistic Doctor

• At MGI Clinics, our Mind Gut Immunity Method focuses on identifying and reversing the root causes of inflammation, offering tailored plans for long-term relief.

‍Why Choose a Holistic Doctor for Ulcerative Colitis?

Traditional treatments often focus on suppressing symptoms with medications, but a holistic doctor addresses the underlying causes of inflammation. At MGI Clinics, we believe in empowering patients to take charge of their health through natural, sustainable strategies.

Our approach combines advanced diagnostic tools with personalized coaching to optimize gut health, improve diet, and support overall well-being.

‍Take Control of Your Health

If you’re looking for lasting relief from ulcerative colitis, consider exploring a holistic approach. Schedule a discovery call with MGI Clinics today to learn how we can help you reverse inflammation, restore gut health, and reclaim your quality of life.

For personalized guidance and support, schedule a discovery call with Dr. Chanu Dasari at MGI Clinics. Our Case Studies page features stories of patients who have successfully managed their conditions through the Mind-Gut-Immunity Method. 

Let us guide you on your journey to health and wellness.

Start Your Journey to Better Health Today

Discover the transformative power of the Mind-Gut-Immunity Method! Over the past decade, Dr. Dasari has helped countless clients reduce inflammation and find relief from autoimmune issues, often in just 3-6 weeks. Now, you can start your journey to better health with our free training. Click the link below, choose your condition, and learn how our proven approach can help you feel better fast.

About the Author

Dr. Chanu Dasari, a distinguished clinician with a career spanning renowned institutions like Vanderbilt University, Oxford University, and the University of California, has made significant contributions to medical research and practice. His work, published in top peer-reviewed scientific journals and adopted by the US Department of Health, highlights his commitment to advancing healthcare. Dr. Dasari is board-certified by the American Board of Medical Specialties and the American College of Surgeons, with a specialization in hernia repair, gallbladder removal, cysts, digestive disease, and cancer. As the founder of the Mind-Gut-Immunity Clinic, he draws from personal experience with autoimmune and digestive dysfunction to lead a team dedicated to patient-centered care using evidence-based protocols.